Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.1
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 1 drop (0.001 fl oz/ 0.028 ml)
Amount Per Serving
%DV
Vitamin D (as cholecalciferol)
10 mcg (400 IU)
100%
Top Medical Research Studies
9
We set out to explore how vitamin D impacts the formation of foam cells from vascular smooth muscle cells (VSMCs), which are key players in the development of atherosclerosis. Our investigation centered on whether vitamin D could suppress the creation of these foam cells and the potential involvement of a receptor called Toll-like receptor 4 (TLR4) in this process.
Using ApoE-/- mice, we assessed the effects of vitamin D supplementation on atherosclerotic plaque formation and looked at the expression of important genes related to cholesterol transport and TLR4. The results were promising—supplemental vitamin D significantly reduced the formation of foam cells and atherosclerotic plaques in the aorta. We noticed that vitamin D not only decreased the expression of TLR4 and other foam cell markers but also encouraged the upregulation of cholesterol transport proteins that help maintain healthy cell function.
In laboratory conditions, vitamin D proved effective in reducing the uptake of oxidized LDL by VSMCs while enhancing the efflux of cholesterol. Notably, we discovered that knocking down TLR4 impaired foam cell formation, suggesting its critical role in this process.
Overall, our findings highlight that vitamin D might be a protective agent against cardiovascular disease by reducing foam cell formation through the JNK-TLR4 signaling pathway. This suggests a potential avenue for dealing with atherosclerotic disease through vitamin D treatment.
Using ApoE-/- mice, we assessed the effects of vitamin D supplementation on atherosclerotic plaque formation and looked at the expression of important genes related to cholesterol transport and TLR4. The results were promising—supplemental vitamin D significantly reduced the formation of foam cells and atherosclerotic plaques in the aorta. We noticed that vitamin D not only decreased the expression of TLR4 and other foam cell markers but also encouraged the upregulation of cholesterol transport proteins that help maintain healthy cell function.
In laboratory conditions, vitamin D proved effective in reducing the uptake of oxidized LDL by VSMCs while enhancing the efflux of cholesterol. Notably, we discovered that knocking down TLR4 impaired foam cell formation, suggesting its critical role in this process.
Overall, our findings highlight that vitamin D might be a protective agent against cardiovascular disease by reducing foam cell formation through the JNK-TLR4 signaling pathway. This suggests a potential avenue for dealing with atherosclerotic disease through vitamin D treatment.
Read More
8
Vitamin D's role in heart health
We explored the relationship between serum vitamin D levels and the risk of cardiovascular disease, as well as all-cause and cancer mortality. Using data from over 11,500 adults aged 40 and older, we wanted to understand whether having higher amounts of this nutrient in our blood could lead to better health outcomes.
Our investigation focused on seeing if the connections between vitamin D and mortality were influenced by inflammation in the body. What we found was intriguing: higher serum levels of vitamin D were linked to lower risks of dying from heart disease and other causes, suggesting that maintaining sufficient vitamin D could be beneficial for heart health.
Additionally, we observed that these benefits might be partly due to reduced inflammation, as measured by biomarkers like C-reactive protein and white blood cell counts. This points to a promising area of research where vitamin D not only plays a role in overall health but could also reduce inflammation, which is a key player in cardiovascular conditions.
Our investigation focused on seeing if the connections between vitamin D and mortality were influenced by inflammation in the body. What we found was intriguing: higher serum levels of vitamin D were linked to lower risks of dying from heart disease and other causes, suggesting that maintaining sufficient vitamin D could be beneficial for heart health.
Additionally, we observed that these benefits might be partly due to reduced inflammation, as measured by biomarkers like C-reactive protein and white blood cell counts. This points to a promising area of research where vitamin D not only plays a role in overall health but could also reduce inflammation, which is a key player in cardiovascular conditions.
Read More
8
We wanted to understand how vitamin D levels affect cardiovascular health, specifically among individuals with type 2 diabetes. Our study involved 1,378 hospitalized patients, examining their vitamin D status and its relationship with cardiovascular disease (CVD).
We found that patients with lower levels of vitamin D were more likely to experience CVD. The research revealed that those deficient in vitamin D had a 1.25 times greater risk of heart disease compared to those with sufficient vitamin D levels. This relationship was particularly strong among women, older adults, and individuals dealing with obesity.
Additionally, we observed significant links between vitamin D deficiency and various cardiometabolic risk factors, including overweight/obesity, high blood pressure, and unhealthy lipid levels. This highlights the potential role of vitamin D in managing heart health, especially for those living with diabetes.
We found that patients with lower levels of vitamin D were more likely to experience CVD. The research revealed that those deficient in vitamin D had a 1.25 times greater risk of heart disease compared to those with sufficient vitamin D levels. This relationship was particularly strong among women, older adults, and individuals dealing with obesity.
Additionally, we observed significant links between vitamin D deficiency and various cardiometabolic risk factors, including overweight/obesity, high blood pressure, and unhealthy lipid levels. This highlights the potential role of vitamin D in managing heart health, especially for those living with diabetes.
Read More
Most Useful Reviews
8
Recommended for everyone
These vitamins are excellent, though it’s essential to be tested and consult a nutritionist. In today’s world, living without vitamins is challenging. The quality is impressive, and I wholeheartedly recommend them. With the proper dosage, these vitamins have a positive impact on skin health, the heart, and the cardiovascular system.
Read More
8.5
Convenient for children
I highly recommend Carlson Labs Children's Vitamin D3. This product has a great formulation, is free from allergy-inducing additives, and is easily accepted by my baby. I take it myself as well. This supplement supports bones, dental health, immunity, cardiovascular health, and overall growth and development in children.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.1
- All Researches
9
We set out to explore how vitamin D impacts the formation of foam cells from vascular smooth muscle cells (VSMCs), which are key players in the development of atherosclerosis. Our investigation centered on whether vitamin D could suppress the creation of these foam cells and the potential involvement of a receptor called Toll-like receptor 4 (TLR4) in this process.
Using ApoE-/- mice, we assessed the effects of vitamin D supplementation on atherosclerotic plaque formation and looked at the expression of important genes related to cholesterol transport and TLR4. The results were promising—supplemental vitamin D significantly reduced the formation of foam cells and atherosclerotic plaques in the aorta. We noticed that vitamin D not only decreased the expression of TLR4 and other foam cell markers but also encouraged the upregulation of cholesterol transport proteins that help maintain healthy cell function.
In laboratory conditions, vitamin D proved effective in reducing the uptake of oxidized LDL by VSMCs while enhancing the efflux of cholesterol. Notably, we discovered that knocking down TLR4 impaired foam cell formation, suggesting its critical role in this process.
Overall, our findings highlight that vitamin D might be a protective agent against cardiovascular disease by reducing foam cell formation through the JNK-TLR4 signaling pathway. This suggests a potential avenue for dealing with atherosclerotic disease through vitamin D treatment.
Using ApoE-/- mice, we assessed the effects of vitamin D supplementation on atherosclerotic plaque formation and looked at the expression of important genes related to cholesterol transport and TLR4. The results were promising—supplemental vitamin D significantly reduced the formation of foam cells and atherosclerotic plaques in the aorta. We noticed that vitamin D not only decreased the expression of TLR4 and other foam cell markers but also encouraged the upregulation of cholesterol transport proteins that help maintain healthy cell function.
In laboratory conditions, vitamin D proved effective in reducing the uptake of oxidized LDL by VSMCs while enhancing the efflux of cholesterol. Notably, we discovered that knocking down TLR4 impaired foam cell formation, suggesting its critical role in this process.
Overall, our findings highlight that vitamin D might be a protective agent against cardiovascular disease by reducing foam cell formation through the JNK-TLR4 signaling pathway. This suggests a potential avenue for dealing with atherosclerotic disease through vitamin D treatment.
Read More
8
Our study delved into the potential benefits of vitamin D3 in improving cardiovascular health, particularly among hypertensive patients suffering from obesity and obstructive sleep apnea (OSA). We designed a randomized clinical trial where participants received either dapagliflozin (an SGLT-2 inhibitor), vitamin D3, a combination of both, or no treatment over a period of 16 weeks.
We evaluated various health parameters including weight, blood pressure, blood sugar levels, and heart function, and analyzed their impact on participants' quality of life. Interestingly, our results indicated that when vitamin D3 was combined with SGLT2 inhibitors, there were notable improvements in several cardio-metabolic outcomes and quality of life measures.
This finding suggests that the dual approach could be a promising strategy in managing cardiovascular risks associated with obesity and OSA. Though our study does not isolate the effects of vitamin D3 alone on cardiovascular disease, it highlights its potential role when paired with other treatments, offering a glimmer of hope for patients dealing with these health challenges.
We evaluated various health parameters including weight, blood pressure, blood sugar levels, and heart function, and analyzed their impact on participants' quality of life. Interestingly, our results indicated that when vitamin D3 was combined with SGLT2 inhibitors, there were notable improvements in several cardio-metabolic outcomes and quality of life measures.
This finding suggests that the dual approach could be a promising strategy in managing cardiovascular risks associated with obesity and OSA. Though our study does not isolate the effects of vitamin D3 alone on cardiovascular disease, it highlights its potential role when paired with other treatments, offering a glimmer of hope for patients dealing with these health challenges.
Read More
8
Vitamin D benefits blood pressure management
We examined the role of vitamin D supplementation in managing hypertension, particularly its effects on cardiovascular health. After analyzing data from a systematic review and meta-analysis that included 24 relevant studies, we discovered that vitamin D has significant benefits for blood pressure.
The findings revealed that vitamin D supplementation was linked to a notable reduction in both systolic and diastolic blood pressure. Specifically, vitamin D led to a decrease in systolic blood pressure by an average of 2.83 mmHg and diastolic blood pressure by 1.64 mmHg. This is promising news for those looking to manage hypertension more effectively.
Unlike calcium and magnesium, which only significantly lowered diastolic blood pressure but didn't impact systolic blood pressure or pulse rate, vitamin D showed consistent and significantly positive outcomes. Therefore, incorporating vitamin D into treatment plans for hypertensive patients could be a beneficial step toward improving cardiovascular health.
The findings revealed that vitamin D supplementation was linked to a notable reduction in both systolic and diastolic blood pressure. Specifically, vitamin D led to a decrease in systolic blood pressure by an average of 2.83 mmHg and diastolic blood pressure by 1.64 mmHg. This is promising news for those looking to manage hypertension more effectively.
Unlike calcium and magnesium, which only significantly lowered diastolic blood pressure but didn't impact systolic blood pressure or pulse rate, vitamin D showed consistent and significantly positive outcomes. Therefore, incorporating vitamin D into treatment plans for hypertensive patients could be a beneficial step toward improving cardiovascular health.
Read More
8
Vitamin D's role in heart health
We explored the relationship between serum vitamin D levels and the risk of cardiovascular disease, as well as all-cause and cancer mortality. Using data from over 11,500 adults aged 40 and older, we wanted to understand whether having higher amounts of this nutrient in our blood could lead to better health outcomes.
Our investigation focused on seeing if the connections between vitamin D and mortality were influenced by inflammation in the body. What we found was intriguing: higher serum levels of vitamin D were linked to lower risks of dying from heart disease and other causes, suggesting that maintaining sufficient vitamin D could be beneficial for heart health.
Additionally, we observed that these benefits might be partly due to reduced inflammation, as measured by biomarkers like C-reactive protein and white blood cell counts. This points to a promising area of research where vitamin D not only plays a role in overall health but could also reduce inflammation, which is a key player in cardiovascular conditions.
Our investigation focused on seeing if the connections between vitamin D and mortality were influenced by inflammation in the body. What we found was intriguing: higher serum levels of vitamin D were linked to lower risks of dying from heart disease and other causes, suggesting that maintaining sufficient vitamin D could be beneficial for heart health.
Additionally, we observed that these benefits might be partly due to reduced inflammation, as measured by biomarkers like C-reactive protein and white blood cell counts. This points to a promising area of research where vitamin D not only plays a role in overall health but could also reduce inflammation, which is a key player in cardiovascular conditions.
Read More
8
We wanted to understand how vitamin D levels affect cardiovascular health, specifically among individuals with type 2 diabetes. Our study involved 1,378 hospitalized patients, examining their vitamin D status and its relationship with cardiovascular disease (CVD).
We found that patients with lower levels of vitamin D were more likely to experience CVD. The research revealed that those deficient in vitamin D had a 1.25 times greater risk of heart disease compared to those with sufficient vitamin D levels. This relationship was particularly strong among women, older adults, and individuals dealing with obesity.
Additionally, we observed significant links between vitamin D deficiency and various cardiometabolic risk factors, including overweight/obesity, high blood pressure, and unhealthy lipid levels. This highlights the potential role of vitamin D in managing heart health, especially for those living with diabetes.
We found that patients with lower levels of vitamin D were more likely to experience CVD. The research revealed that those deficient in vitamin D had a 1.25 times greater risk of heart disease compared to those with sufficient vitamin D levels. This relationship was particularly strong among women, older adults, and individuals dealing with obesity.
Additionally, we observed significant links between vitamin D deficiency and various cardiometabolic risk factors, including overweight/obesity, high blood pressure, and unhealthy lipid levels. This highlights the potential role of vitamin D in managing heart health, especially for those living with diabetes.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8
Recommended for everyone
These vitamins are excellent, though it’s essential to be tested and consult a nutritionist. In today’s world, living without vitamins is challenging. The quality is impressive, and I wholeheartedly recommend them. With the proper dosage, these vitamins have a positive impact on skin health, the heart, and the cardiovascular system.
Read More
8.5
Convenient for children
I highly recommend Carlson Labs Children's Vitamin D3. This product has a great formulation, is free from allergy-inducing additives, and is easily accepted by my baby. I take it myself as well. This supplement supports bones, dental health, immunity, cardiovascular health, and overall growth and development in children.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Vanreusel I, Hens W, Van Craenenbroeck EM, Paelinck BP, Segers VFM, et al. Vitamin D levels correlate with exercise capacity in adults with CHD. Cardiol Young. 2025. doi:10.1017/S1047951125000526
- Fang X, Zhang J, Zhang Z, Ye D. Association between Vitamin D and mortality risk in gout patients. J Public Health (Oxf). 2025. doi:10.1093/pubmed/fdaf010
- Loh HH, Tay SP, Koa AJ, Yong MC, Said A, et al. Unveiling the benefits of Vitamin D3 with SGLT-2 inhibitors for hypertensive obese obstructive sleep apnea patients. J Transl Med. 2025;23:296. doi:10.1186/s12967-025-06312-w
- Amer SA, Abo-Elnour DE, Abbas A, Abdelrahman AS, Hamdy HM, et al. Calcium, magnesium, and vitamin D supplementations as complementary therapy for hypertensive patients: a systematic review and meta-analysis. BMC Complement Med Ther. 2025;25:89. doi:10.1186/s12906-025-04809-x
- Checa-Ros A, Locascio A, Okojie OJ, Abellán-Galiana P, D'Marco L. Perirenal fat differs in patients with chronic kidney disease receiving different vitamin D-based treatments: a preliminary study. BMC Nephrol. 2025;26:119. doi:10.1186/s12882-025-04041-2
- Liu C, Wongsonegoro H, Sheng T, Fan H, Zhang J. Associations between serum micronutrients and all-cause, cancer, and cardiovascular mortality in a national representative population: Mediated by inflammatory biomarkers. Redox Biol. 2025;81:103573. doi:10.1016/j.redox.2025.103573
- Zhang N, Wang Y, Li W, Wang Y, Zhang H, et al. Association between serum vitamin D level and cardiovascular disease in Chinese patients with type 2 diabetes mellitus: a cross-sectional study. Sci Rep. 2025;15:6454. doi:10.1038/s41598-025-90785-8
- Zhang X, Liu J, Han L, Luo G, Jiang P, et al. Vitamin D reduces VSMC foam cell formation and protects against AS progression. J Endocrinol. 2025;265. doi:10.1530/JOE-24-0056
- Haghighatafshar M, Shekasteband B, Firuzyar T, Etemadi Z, Farhoudi F, et al. The Impact of Vitamin D Deficiency on Coronary Artery Disease Severity Based on Myocardial Perfusion Imaging: A Cross-Sectional Study. Iran J Med Sci. 2025;50:31. doi:10.30476/ijms.2024.101112.3372
- Bulfone L, Vacca A, Brosolo G, Da Porto A, Bertin N, et al. Subclinical Carotid Disease Is Associated with Low Serum Vitamin D in Nondiabetic Middle-Aged Hypertensive Patients. Nutrients. 2025;17. doi:10.3390/nu17030480
- Li Q, Tong Y, Guo J, Liang X, Shao H, et al. Vitamin D Receptor Regulates Oxidative Stress and Apoptosis Via the HIF-1α/HO-1 Pathway in Cardiomyocytes. Cell Biochem Biophys. 2025. doi:10.1007/s12013-025-01681-x
